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March 21 is World Down Syndrome Day.

Ahead of the global day, 50 mothers and their children, who have Down syndrome, took part in a moving ‘Carpool Karaoke’ video.

In the video, the moms and their children are seen lip syncing and using signs to the song “A Thousand Years” by Christina Perri.

Perri took to Twitter to support and praise the video, saying she is “honored” they chose her song.

Late-night TV host James Corden, who is known for his “Carpool Karaoke” segments, called the video “the most beautiful Carpool Karaoke ever.”

The mother’s are part of a Facebook group known as “Designer Genes” created for parents who have a child with Down syndrome.

The group wants to raise awareness about the vital role people with Down syndrome play in society.

Watch the full video in the player above